Reply to comments
Reply is especially useful in shared reviews, enabling participants to read each other’s comments. Upon creation, replies appear directly in the pop-up notes and in the Comment panel. Replies are shown below the original comments. You can hover the cursor over a comment on the document page to see all replies under it. However, if you create any sub-reply (replying to an existing reply), the pop-up notes will only show the number of sub-replies under the parent reply, meaning you need to open the Comment Panel to see them all. Sub-replies also cannot be edited directly within the pop-up notes.
Reply in the comment list
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Open a PDF and do either of the following to open the Comment panel:
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Choose Comment > Comment Processing > Comment Panel.
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On the Sidebar Navigation pane, click on the Comment icon
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Select a comment in the Comment panel. Right-click on it and select Reply from the pop-up menu.
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Type you reply in the box (A) that appears below the comment.

Reply in the pop-up note
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Open a PDF and double-click a comment to open its pop-up note.
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Right-click on the pop-up note and select Reply from the pop-up menu.
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Type your reply in the box that appears below the comment.

Replies appear right below the comment, both in the pop-up note (Right) and in the Comment panel (Left).